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The cost is pharmacologic surface area: more pathways engaged means more systems that can produce unwanted effects, and glucagon receptor agonism in particular has to be balanced carefully against the glucose-lowering arms of the molecule
Deficiency causes megaloblastic anemia abnormally large, dysfunctional red cells that impair oxygen delivery, producing fatigue, shortness of breath, and pallor
Research on obese mice showed that chronic AOD-9604 treatment reduced both subcutaneous and visceral fat mass, with visceral reductions being proportionally greater
Where Phase I or Phase II human trials exist, they are noted in the compound page summary
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