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A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)
IM injections involve the direct administration of vitamin B12 into the muscle tissue, typically in the form of hydroxocobalamin or methylcobalamin
Checking your B12 levels is key to making sure your injections are working
Most vitamin b12 injections you will handle in a UK clinic are therefore 1mg/1ml hydroxocobalamin ampoules, supplied ready to use with no reconstitution required
Some clinicians recommend microdosing tirzepatide as a maintenance strategy after achieving target weight
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