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A: A dose-dependent human signal in a multiple ascending dose study, which helped establish feasibility and tolerability for the weekly dosing model

While historical interventions focus on non-specific systemic fluid reduction or destructive vestibular ablation, targeted pharmacotherapies such as SPI-1005 (Ebselen) attempt to address localized metabolic stress

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N-Acetylcysteine (NAC) for Glutathione Synthesis Support N-acetylcysteine, a precursor to glutathione, provides the rate-limiting cysteine amino acid necessary for glutathione synthesis