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Weinberg ED
To summarize Maintaining focus on your weight loss goals is crucial, regardless of where you are in your journey
This concept eventually led to drugs like sitagliptin (approved 2006), but those would generally have less potent effects than direct GLP-1 agonists since GLP-1 levels only double or triple on DPP-4 inhibitors (and those drugs rely on some residual pancreatic function and meal stimulation) ( [59] )
For many patients, the choices that felt impossible before smaller portions, less snacking, fewer cravings start to happen naturally, without the fight
For providers, the key opportunity lies in recognizing when factors such as oxidative stress, environmental exposures, or metabolic strain may be shaping a patients presentation
