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Semaglutide is a long-acting Glucagon-like peptide-1receptor agonist (GLP-1Ra) that is available as a once-weekly subcutaneous (at doses up to 2.4 mg) and as a once-daily oral (at doses up to 14 mg) and has been shown to have the most potent effect on glucose lowering and weight loss within the class [58,59]
Daily logistics The combined protocol involves daily tesamorelin injections (morning, fasting) plus weekly retatrutide injections (any time, rotated sites)
They have a direct anti-inflammatory effect of their own
![Structure of [ 3 H]liraglutide (top) and the GLP-1 receptor agonists](https://www.researchgate.net/profile/Inga-Bjornsdottir-2/publication/45650716/figure/fig2/AS:667822585806848@1536232720030/Structure-of-3-Hliraglutide-top-and-the-GLP-1-receptor-agonists-liraglutide-and.png)
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