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Instead, OX-A exhibits a clear stimulatory effect of NPY neurons of the ARC (which stimulates SST in the PeN, leading to GH inhibition) and a inhibitory effect on GHRH neurons located in the parvocellular region of the paraventricular nucleus of the hypothalamus (PVH), which project axons to fenestrated capillaries of portal vessels in the median eminence (ME), indicating a specific targeting of orexins on these neurons [51,52,53]

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