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It has been confirmed that patients with T2DM have a higher risk of developing NDD, including AD, PD, amyotrophic lateral sclerosis and Huntingtons disease, which in these patients are accompanied by more pronounced motor deficits and faster disease progression
A supervised trial of berberine and semaglutide is generally not a good idea if you: Have a history of severe hypoglycemia Have advanced liver or kidney disease Are pregnant, planning pregnancy, or breastfeeding Have complex polypharmacy (multiple meds that rely on CYP3A4/CYP2D6) Have a history of pancreatitis or serious GI motility disorders (which already restrict semaglutide use) If any of these apply, talk with your clinician about safer alternatives
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Well also coordinate with your prescribing clinician to ensure timing aligns with your GLP-1 medication schedule and overall health goals
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