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A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed

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doi:10.1007/s00125-007-0793-y

Other conditions that make Vitamin B12 absorption more difficult are: Weight loss surgery or another operation that removed part of your stomach Heavy drinking Taking acid-reducing medication for a long time Certain health issues may also lead to the development of vitamin B12 deficiency such as atrophic gastritis, pernicious anemia, Crohns disease, celiac disease, immune system disorders, Graves disease and lupus

Low B12 in the body is also associated with having poor energy, frequent fatigue, and weakness