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The peptide is created by the inclusion of 13 amino acids to the N-terminus of native IGF-1 and by replacing the glutamic acid at position 3 with arginine, which ultimately leads to the formation of an 83 amino acid peptide
Moreover, Largo, et al showed that treatment with GS suppressed IL-1-induced COX-2 expression through transcriptional downregulation and suppression of NF-B DNA binding activity in human chondrocytes 22 , and as well, decreased COX-2 expression on peripheral blood mononuclear cells in rabbits with atherosclerosis aggravated by chronic arthritis 32
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Davies MJ, Bain SC, Atkin SL, et al
Groop PH, Cooper ME, Perkovic V, et al
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