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The major conformational dynamics of AMY 1 R-Gs and AMY 2 R-Gs bound to individual peptide agonists were primarily related to motions of the combined RAMP:CTR ECD relative to the TM core, and this was also true for previously determined AMY 3 R-Gs complexes with rAmy (Fig

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This dysfunction leads to reduced ATP production and increased ROS formation, which results in oxidative stress and neuronal damage