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Development of a novel drug delivery system to deliver drugs directly to the colonic mucosa, resulting in improved efficacy and reduced systemic exposure for the treatment of ulcerative colitis

[169] reported that SOCS1 and SOCS3 induced IR by inhibiting the phosphorylation of tyrosine moieties on IRS proteins in mouse adipocytes, muscle cells, and liver tissue

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Missing injectable doses once per week is much harder than missing daily oral doses

Lipid levels are well within acceptable range therefore advisable to review necessity for its continued prescription especially since there is acceptable glycaemic control