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It is important to understand that GLP-1 medications require dose titration starting at a lower dose and gradually increasing over several weeks or months
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In clinical trials, including a Phase 2 study published in the New England Journal of Medicine (2023), it has been administered as a subcutaneous injection injected beneath the skin typically once weekly
If severe, it may be treated with TAVR valve replacement surgery
It inhibits nuclear translocation of NF-B and reduces pro-inflammatory cytokine output
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