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Duran M, Willis JR, Dalvi N, Fokakis Z, Virkus SA, Hardaway JA (2025) Integration of Glucagon-Like Peptide 1 Receptor Actions Through the Central Amygdala

Gastrointestinal Problems Remain the Most Common GLP-1 Side Effects Most patients are already familiar with the digestive complaints associated with drugs like semaglutide and tirzepatide: nausea vomiting diarrhea constipation abdominal discomfort heartburn bloating Drug companies warn about these reactions because they were frequently observed during clinical trials

As extensive as these metabolic changes were, and although they possess concordance with the functional and vascular changes previously demonstrated in our lab, they must be acknowledged to be preliminary and limited in their failure to display the full profile of ischemic myocardial GLP-1 agonism

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