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Following the SUSTAIN-6 findings, the Ozempic Summary of Product Characteristics (SmPC) and specialist ophthalmology guidance emphasise the importance of: Assessing retinopathy status before initiating semaglutide Ensuring patients are up-to-date with diabetic eye screening Considering the rate of anticipated glycaemic improvement More frequent monitoring in high-risk individuals The consensus among UK diabetes specialists is that semaglutide remains an important therapeutic option, but prescribers should exercise particular caution in patients with established retinopathy and poor baseline glycaemic control
Once MASLD is diagnosed, staging the degree of fibrosis or cirrhosis is crucial, as well as a cardiovascular risk assessment and managing other co-existing conditions
Note: this is an ever changing environment and there is recent news that Novo Nordisk (Wegovy) has ended their partnership with Hims
China has now approved GLP-1 therapies from Eli Lilly (Mounjaro), Innovent Biologics (mazdutide), and Guangzhou Innogen (efsubaglutide alfa), in addition to Xianyida
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