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To further explore the long-term trajectories of GLP-1RAs, we also conducted subgroup analyses of the placebo-subtracted groups based on the follow-up periods: 12 18 weeks, 24 30 weeks, 48 56 weeks, 68 78 weeks and 104 weeks

Semaglutide targets one hormone pathway (GLP-1), while tirzepatide targets two (GLP-1 and GIP) and in head-to-head-style trial data of the branded molecules, tirzepatide produced larger average weight loss

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The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration

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