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Thus, CTLs facilitate choline transport across the plasma and mitochondrial membranes, aiding in the production of phosphatidylcholine (PC) and betaine, respectively ( Figure 1 Figure 2 Once intracellular, choline is directed into various metabolic pathways, including 1) its oxidation to form mitochondrial betaine, 2) its acetylation to produce ACh, and 3) its initial phosphorylation followed by mobilization in the Kennedy pathway to generate cholie-containing phospholipids ( Figure 2 )

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