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The activation of the classical cAMP pathway is achieved by releasing irritating G protein subunit Gs through the exchange of guanine nucleotide and the activation/dissociation of heterogeneous trimer G protein, and in pancreatic cells, GLP-1 binds to the specific guanine nucleotide-binding protein-coupled receptor GLP-1R, leading to adenylyl cyclase activation and elevated cAMP levels (Mayo et al., 2003

[23] NICE guidance emphasises that GLP-1 medications should be combined with lifestyle modifications, including dietary changes and increased physical activity, to optimise outcomes

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