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This dual mechanism produces greater weight loss in head-to-head comparisons, with clinical trials showing approximately 20-22% body weight reduction

The anticancer monosaccharide xylitol (100) and natural Chinese herbal extracts, including dihydroartemisinin (66), artesunate (67), glaucocalyxin A (140), and tanshinone IIA (162), upregulate Prostaglandin-Endoperoxide Synthase 2, p53 and ChaC1 expression

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2c), with enriched mutations such as Asp161Asn, Asn164Lys, Asn235Ile, Ser279Pro and Ser280Pro likely contributing to this gain (Supplementary Table 1)

Long-term effects of intensive glucose lowering on cardiovascular outcomes