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The addition of glucagon receptor activation increases energy expenditure and fat oxidation beyond what GLP-1 alone can achieve

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Giugliano, Free and fixed-ratio combinations of basal insulin and GLP-1 receptor agonists versus basal insulin intensification in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

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These include: Insulin injections , which are commonly prescribed and have been proven safe for use during pregnancy

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