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Type III IFNs have been shown to exert antifungal and antiviral effects predominantly in neutrophils through JAK/STAT signaling
The histidine residue is essential for catalysis in HPII, and the side chain of valine residue makes the channel narrower to a diameter of about 3 that prevents any molecule larger than H 2 O and H 2 O 2 from gaining access to the active site
Borthakur G, Ofran Y, Nagler A, Rowe J, Foran J, Uy GL, DiPersio JF, Altman JK, Frankfurt O, Tallman MS, Peled A, Pereg Y, Vainstein A, Aharon A, AlRawi A, McQueen T, Pemmaraju N, Bueso-Ramos C, Cortes JE, Andreeff M
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