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The peptide modulates several key neurotransmitter systems: dopamine (motivation and reward), serotonin (mood regulation), GABA (your brain's primary calming signal), and nitric oxide (blood flow regulation, including cerebral circulation)
Several randomized, placebo-controlled trials indicate that metformin therapy leads to a progressive decline in vitamin B12 levels and can cause physiologically significant deficiency (153)
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It is worth noting that unlicensed medicines can be lawfully supplied in limited circumstances for example, as 'specials' manufactured to meet the specific clinical needs of an individual patient under a prescriber's direction
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