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The problem with native GLP-1 is that it has a half-life of roughly 2 minutes the enzyme dipeptidyl peptidase-4 (DPP-4) degrades it almost instantly
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J Neurodev Disord 9 , 14
The FDA does require a boxed warning for GLP-1 receptor agonists (Wegovy, Saxenda) and the dual GIP/GLP-1 receptor agonist tirzepatide (Zepbound) regarding thyroid C-cell tumors, based on rodent studies, though human relevance remains uncertain
Prades R, Teixid M, Oller-Salvia B (2025) New trends in brain shuttle peptides
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