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Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, openlabel, phase 3, non-inferiority study
Semaglutide provides the core metabolic benefits: appetite suppression, improved insulin sensitivity, reduced glucagon secretion, and delayed gastric emptying
Gervais, M., Labouebe, G., Picard, A., Thorens, B
This trial also stopped people abruptly and removed their lifestyle support at the same time, rather than tapering the dose gradually, which is closer to standard medical practice for many medications
This approach, known as gradual dose adjustment, gives your body more time to adjust to the medication at a slower pace, potentially reducing side effects like nausea
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