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This decreases venous reflux and venous pressure

Longer-term use (6+ months) may create more durable improvements where enhanced dermal architecture supports ongoing collagen synthesis at rates intermediate between treatment peaks and pre-treatment baseline, potentially maintaining 40-60% of peak improvements indefinitely without continuous peptide application

doi:10.1080/19390211.2016.1188193

341 For instance, treatment with nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF) enhances neurite outgrowth and supports neuronal survival

ESTHER FORMULA Glutathione Direct 5X SKIN WHITENING : Glutathione reduces melanogenesis by suppressing free radicals including reactive oxygen and nitrogen