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This interaction seems to be most apparent when berberine is administered 2 hours prior to metformin
Some of these compounds are wellknown byproducts of microbial fermentation, especially associated with the proliferation of yeast species (e.g., Aspergillus), which are frequently identified as dominant organisms in dysbiotic gut environments 18
doi: 10.1016/j.imlet.2021.10.003 53 NieXChenYChenYChenCHanBLiQet al
No significant heterogeneity was identified across trials on SCD ( I 2 = 0%, P = 0.89)
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