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One analysis found a reporting odds ratio (ROR) of 2.09 for thyroid cancer with tirzepatide, meaning thyroid cancer was reported roughly twice as often as expected

It is engineered to interact with melanocortin receptors (MC1RMC5R), making it a valuable compound for laboratory studies focused on melanocortin signalling, receptor binding dynamics, and peptide-mediated neuroendocrine pathways

Clinical Orthopaedics and Related Research, 2000