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TRIUMPH-2 demonstrated up to 20.8% average weight loss (49.6 lbs) at 80 weeks in adults with obesity or overweight and type 2 diabetes TRIUMPH-3 showed up to 22.6% average weight loss (55.8 lbs) in adults with severe obesity and established cardiovascular disease Retatrutide delivered A1C reductions of up to 1.6% in participants with type 2 diabetes The highest dose improved key cardiometabolic markers, including triglycerides, blood pressure, waist circumference, and inflammation markers Lilly plans to submit a Biologics License Application (BLA) to the FDA in Q1 2027 Advances the next generation of obesity medicines targeting weight management alongside broader metabolic health outcomes ------------------------------------------------------------- Stay up to date with everything obesity through my newsletter To view or add a comment, sign in 876 followers Explore related topics Trends in Glp-1 Treatment Options Advancements in Diabetes and Obesity Treatments Latest Developments in Type 1 Diabetes Research Cardiometabolic Therapies Under Development Impact of Glp-1 Medications on Health How Glp-1 Drugs Impact Economic Trends Recent Advances in Heart Disease Research Gut Metabolites Impact on Cardiovascular Health

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doi: 10.1084/jem.20201129 289 VinciguerraM.RomitiS.FattouchK.De BellisA.GrecoE