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GLP-1 medications are powerful tools, but they work best as part of a comprehensive approach

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Once daily injectable liraglutide (marketed as Victoza for T2DM and Saxenda for obesity) and once weekly injectable semaglutide (marketed as Ozempic for T2DM and Wegovy for obesity) are two additional GLP-1 analogues, sharing 97% and 94% amino acid homology to GLP-1, respectively [ Figure 2 , Table 1 ]

(2005) Incretin mimetics as emerging treatments for type 2 diabetes

Recently, retatrutide (also known as LY3437943) 6,7,8,9 has shown impressive efficacy in obesity treatment through triple agonism at GLP-1R, GIPR and GCGR