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Because they are not easily cleared, very high intakes can build up and cause toxicity
PMID 27886869
[Crossref] Chalupsky K, Kracun D, Kanchev I, Bertram K, Grlach A (2015) Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase
Erectile dysfunction : Men with B12 deficiency may experience erectile dysfunction as a result of increased levels of homocysteine in the body (28)
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