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Higher-dose oral protocols (1000 mcg daily) increase costs to $48-90 monthly

(Shutter, 2019) Hematological: Pancytopenia, thrombocytopenia, neutropenia, folate-dependent megaloblastic anemia, aplastic anemia, pseudolymphoma, and actual lymphoma

The side effects that occur, like reddening of the skin and urine and changes in heart rate and blood pressure are temporary and harmless

Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum

Potential risks include infection, scarring, changes in nipple sensation, difficulty breastfeeding, asymmetry, and in rare cases, partial or total loss of the nipple or areola