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The disulfide bond between Cys182 and Cys189 is critical for the peptide's three-dimensional conformation and biological activity
The majority of the studies (see above in red) are preclinical studies in rodents, the vast majority of which have been done by a single research group in Croatia, which has been rinsing and repeating the same approach for decades
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DSIP modulates sleep-promoting pathways rather than inducing acute sedation
doi:10.4161/oxim.3.1.10476, PMID: 20716923 Morris G, Maes M (2013) Case definitions and diagnostic criteria for myalgic encephalomyelitis and chronic fatigue syndrome: from clinical-consensus to evidence-based case definitions
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