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have shown that inhibition of PSC activation is associated with a decrease in islet fibrosis and an increase in insulin secretion [35], indicating the potential role of PSC activation in -cell failure

For people with chronic obesity and cardiovascular complications, GLP-1 receptor agonists are preferred to amphetamine-based therapies like phentermine, which can worsen blood pressure, heart rate, anxiety, and insomnia

2021;372: m4573

(GLP-1s are thought to curb cravings by targeting the brains reward pathway, which involves the release of dopamine.) So in these patients, too, weight loss is likely and they could also contend with the unwanted aesthetic effects of Ozempic

This early signal reflects the medication's rapid action on brain receptors governing hunger and satiety pathways