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UMFA can accumulate when folic acid intake exceeds the bodys capacity to convert it into biologically active folate, particularly in individuals with reduced activity of the dihydrofolate reductase (DHFR) enzyme, which catalyses the first step in folic acid metabolism
This conversion relies on healthy gut bacteria and adequate co-factors including methylfolate , magnesium , and zinc nutrients that are frequently depleted by environmental toxins and modern lifestyle factors
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