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Minoxidil also upregulates VEGF, but through a different pathway: potassium channel opening and prolyl hydroxylase inhibition (Lachgar et al., 1998)

503,512,518 These effects include modulating cell proliferation, inflammation, and oxidative stress in liver cells, all of which are key factors in the development and progression of HCC

At the same time, in our previous study on the protective effect of Ebselen on renal ischemia-reperfusion injury, we found that the expression level of GPX3 in renal tissues decreased after renal IRI, and when the level of GPX3 increased after the use of Ebselen, the pathological damage of renal histologic damage was alleviated, and we speculated that GPX3 may play an important role in the oxidative stress response of renal ischemia-reperfusion injury (Wu et al., 2022)

Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease

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