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(2024) followed all Danish singleton children born between 1997 and 2015 over a period of 15 years and found that children exposed to SSRIs prenatally had an overall increased risk of childhood disorders of gutbrain interactions (DGBI) (relative risk: 1.08), with the main driver being functional constipation (relative risk: 1.19), suggesting that prenatal SSRI exposure is associated with an increased risk of developing functional constipation

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Besides, APX transcripts mainly consisted of 812 exons, supporting the relatively less conserved structure of APXs compared to GPXs

Firstly, our study further strengthen the evidence of well-designed RCTs of ALC in HE and introduce the view and methodology of evidence-based medicine (EBM) when compared with a previous review included 3 clinical trials reported in 2008.28 Secondly, perhaps more and more investigators from different countries will be interested and highlight the role of ALC and conduct studies with far more important findings, so as to provide another choice drug for HE

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