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For the summary outcomes, we computed the estimates of the random effects using restricted maximum likelihood to estimate the heterogeneity variance, since we assumed clinical variability between the studies

The medication also enhances glucose-dependent insulin secretion while suppressing inappropriate glucagon release, supporting more stable blood sugar levels that reduce energy crashes often triggering hunger and overeating

Its potential role as an antioxidant and its ability to downregulate lipid peroxidation are also key areas of investigation in the field of gerontology

Metformin also leads to GI problems such as diarrhea, nausea and vomiting, and occasionally causes low B12 levels and weight loss