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AMG133 is a monoclonal antibody drug designed to block the glucose-dependent insulinotropic polypeptide (GIP) receptor and simultaneously bind to two modified GLP-1 peptide segments to activate the GLP-1 receptor

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When vomiting or diarrhea occurs, the body loses not only water but also electrolytes, triggering compensatory mechanisms including increased thirst drive

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This hormonal shift causes the metabolic rate to slow by approximately 28% per decade, making it harder to maintain weight even without changes in diet or exercise