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review at 4 mg, 9 mg, 12 mg Best For Mirrors current Phase 3 maintenance arms Approach Slow titration Duration Add 2-4 weeks per dose step when GI symptoms persist Review Point Each dose step Best For When nausea, vomiting, or diarrhea is hard to tolerate Trial protocols allowed participants to stay at the current dose for an extra 2-4 weeks when GI side effects were significant

Semaglutide works by stimulating a hormone called glucagon-like peptide-1 (GLP-1) that targets areas of the brain that regulate appetite and food intake

Laboratory research record on GLP-1S [PMID: 42163990] PubMed laboratory record discussing GLP-1S in a research context

H.SargentD.FordR.et al (2009)

In December 2025, the FDA also approved an oral form of Wegovy specifically for weight loss