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Radioligand and fluorescent binding assays, competition binding, recombinant receptor-expressing cell lines, functional readouts through a defined coupling pathway, and antagonist controls demonstrating that an effect is receptor-mediated
Curr Protoc Neurosci
For example, the combination of the cancer drug Dasatinib and the natural compound Quercetin was shown to induce apoptosis in senescent cells in a variety of contexts in vitro and in vivo 1,4
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