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Hu W, Song R, Cheng R et al (2022) Use of GLP-1 receptor agonists and occurrence of thyroid disorders: a meta-analysis of randomized controlled trials
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Indeed the GLP-1(7-36) NH2 receptor, a GPCR, is found to be expressed by a wide range of tissues and cells such as: , , and -cells (169), sinoatrial node myocytes, arterial smooth muscle cells of lungs and kidneys, megakaryocytes, macrophages, monocytes, lymphocytes, gastrointestinal tract mucosa [mainly Brunner's gland in the duodenum, but also in the parietal cells of the stomach, jejunum ileum and the nerve plexus around the small and large intestine (170, 171)], central nervous system [neocortex, cerebellum, thalamus, amygdala, area postrema, hypothalamus, hippocampus, nucleus tractus solitarius (158)], peripheral nervous system (myenteric plexus) and in the skin (172176)
doi: 10.1038/s41538-023-00197-z 10
Fat Breakdown The GH and IGF-1 rise drives fat breakdown in visceral fat (the deep fat around your organs) more than in fat under the skin
