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In addition to stimulating adrenocorticotropic hormone (ACTH) release from the pituitary and the cascade of events leading to glucocorticoid release, CRH is also released into the arcuate nucleus of the hypothalamus (ARC) to inhibit neuropeptide Y (NPY)/agouti-related peptide (AGRP) neurons there (Heinrichs et al., 1993

They are different expressions of the same biological reality: the body's ability to heal, protect, and renew itself declines across the decades in ways that accelerate disease and compress the years of genuine vitality

In individuals with obesity, GLP-1 secretion from intestinal L-cells may itself be impaired meaning the body is already deficient in the very hormone these medications replace

Drink more water, as adequate water intake is known to improve satiety and improve metabolism (15)