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Efficacy and Safety of Once-Weekly Semaglutide Versus Once-Daily Insulin Glargine as Add-on to Metformin (With or Without Sulfonylureas) in Insulin-Naive Patients With Type 2 Diabetes (SUSTAIN 4): A Randomised, Open-Label, Parallel-Group, Multicentre, Mul
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In type 2 diabetes rat models, where bone mass is often reduced, contrary to humans, where bone mass is often normal or increased, liraglutide administration in the range of ~ 110160 nmol/kg/day resulted in increased trabecular BMD and restoration of trabecular microarchitecture parameters in the appendicular and axial skeleton [63,64,65,66,67]
In these reports, the designation may be high grade dysplasia (or older term, carcinoma in situ)
Weight loss, achieved through a combination of diet, exercise, and lifestyle changes, can help improve GLP-1 levels and insulin sensitivity
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