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Common blood sugar patterns during illness: Elevated morning readings despite eating less Increased variability throughout the day Delayed response to medications Potential for both highs and lows Monitoring During Illness If you have diabetes, increase your blood sugar monitoring during illness: Check at least 4 times daily (morning, before meals, bedtime) Monitor more frequently if readings are above 250 mg/dL or below 70 mg/dL Test for ketones if blood sugar exceeds 250 mg/dL Keep a written log of readings to share with your provider When to Contact Your Doctor For people with diabetes using GLP-1 medications, contact your healthcare provider if: Blood sugar remains above 250 mg/dL despite medication You have ketones in your urine Youre unable to eat or drink for more than 12 hours Youre experiencing severe symptoms Youre unsure about medication dosing during illness Your provider may temporarily adjust your diabetes medication regimen during illness to maintain safe blood sugar levels

Source: Evaluate Pharma, World Obesity Federation, Putnam Analysis Q2, 2025 Unmet Needs and Potential Differentiation Levers Despite extraordinary promise, there are still unmet needs that biopharma companies can target to address: GI Tolerability The most common GI adverse events (nausea, vomiting, and diarrhea) often lead to therapy discontinuation

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Non-surgical energy restriction for weight loss An overall healthy eating plan that results in an energy deficit, in conjunction with medications and/or metabolic surgery as individually appropriate, should be considered to support glycaemic and weight management goals in adults with type 2 diabetes [5, 22]

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