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Therapeutic Strategy: Targeting the GMGLP-1 Axis The authors propose a multi-level intervention framework that moves well beyond GLP-1RA pharmacotherapy alone: Lifestyle foundation : Diet and exercise modulate GM composition, enhance SCFA and bile acid production, and raise endogenous GLP-1 levels simultaneously addressing all four disease processes
It preferentially mobilizes fat stores, particularly visceral fat , for fuel rather than breaking down muscle protein
Those who also adjust their diet and activity tend to see even more, and your provider will set realistic goals with you along the way
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