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VerbalisJGGoldsmithSRGreenbergAKorzeliusCSchrierRWSternsRHet al

ARC GABAergic neurons that express thyrotropin-releasing hormone (TRH), approximately 60% of which expressed GLP-1R, were found to have GABAergic afferents directly targeting AgRP neurons

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doi: 10.1164/ajrccm.163.4.9912132 150 BenitoEBlazquezEBoschMA

To exert these apparent effects, CJC-1295 appears to interact with specific binding sites on the GHRH receptor protein, leading to conformational changes in the receptor structure and potentially initiating a cascade of molecular events