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And they rejected it because they think its too big a molecule

Patients with PD primarily exhibit a significant loss of insulin receptor mRNA in the substantia nigra pars compacta, increased insulin IR, and reduced activation of molecules such as insulin receptor substrate 1 (IRS1) and protein kinase B (Akt) within the insulin metabolic pathway (24)

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Now, researchers at Duke University School of Medicine, in Durham, North Carolina, have discovered a new form of blood sugar regulation, which opens up new avenues to treating type 2 diabetes