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It is a dimeric complex composed of: The calcitonin receptor (CTR) , a GPCR The RAMP protein (Receptor Activity Modifying Protein), 1, 2 or 3 Depending on the type of RAMP, three different amylin receptors arise: AMY1 : CTR + RAMP1, primarily in the CNS (area postrema, hypothalamus) AMY2 : CTR + RAMP2, peripheral tissues AMY3 : CTR + RAMP3, bone tissue, some CNS Cagrilintide activates all three amylin receptors , but the primary therapeutic effect is via AMY1 in the area postrema (brainstem, where nausea and satiety signals are processed)
Many industry analysts believe that small-molecule GLP-1 drugs may offer long-term advantages in manufacturing scalability and production costs an important point that continues to shape oral GLP-1 drug development trends
Source: Bertalan Mesk, MD, PhDs Post Should diabetics currently on GLP-1 agonists wear continuous glucose monitoring devices (CGMs)
Weekly weigh-ins at the same time under the same conditions (morning, after bathroom, before eating) provide trend data without the noise of daily fluctuations
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