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139,140 Compared with either drug monotherapy, combination therapy with PDL1 and APG-115 resulted in increased antitumor effects, whereas this effect was not observed in Trp53-knockout mice, which further demonstrated that p53 activation is essential for the TME

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Signal mining and statistical analysis Disproportionality analysis serves as a crucial tool for pharmacovigilance to identify potential drug-event safety signals 23

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