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If discomfort continues beyond a month, a medical review helps rule out hydration, nutrition, or dosing issues

The search strategy details are provided in Additional file 1: Table S1

However, other formulations are specifically designed to be taken with meals

Protein synthesis and folding By regulating the reduction state of protein thiol groups, glutathione helps proteins maintain their correct spatial structure and ensure their normal function

La evidencia cientfica pone de manifiesto que se trata de una afeccin compleja y multifactorial, en la que influyen desde factores biolgicos y genticos hasta factores socioeconmicos y ambientales o las horas de sueo