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Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea

While chronic exposure to GLP-1Ra appears to be essentially neutral on both systolic and diastolic function, irrespective of left ventricular ejection fraction (LVEF), a beneficial impact of SGLT-2i is consistently detectable for both systolic and diastolic function parameters in subjects with diabetes with and without HF, with a gradient proportional to the severity of baseline dysfunction

GLP-1 use during early pregnancy may not increase risk of major adverse outcomes Taking GLP-1s during the first trimester of pregnancy does not appear to substantially increase the risk of adverse outcomes, according to a new study led by Harvard T.H

In Phase 3 clinical trials, it helped adults without diabetes lose up to 22.7% of their body weight over 68 weeks, and adults with type 2 diabetes lose up to 15.7%

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